Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle.Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of efficacy and potential liver toxicities.As post-translational modifications in T cell epitopes have the
Abstract In order to answer the question on how much the trilinear Higgs self-coupling could deviate from its Standard Model value in regent 250ml price weakly coupled models, we study both theoretical and phenomenological constraints.As a first step, we discuss this question by modifying the Standard Model using effective operators.Considering con
Animated pedagogical agents are lifelike virtual characters designed to augment learning.A review of developmental psychology literature led to the hypothesis that the temporal contingency of such agents would promote human learning.We developed a Pedagogical Agent with Gaze Interaction solo jec 10 (PAGI), an experimental animated pedagogical agent